For Healthcare Providers

Re-Awaken Skin From Within

DISCOVER RADIESSE

Re-Awaken Skin From Within

Your skin possesses an incredible, innate power to renew itself. Discover how RADIESSE can activate your skin’s own natural process to target visible signs of aging in the face and beyond.

Discover where regeneration can take you

RADIESSE uses an ingredient that is also naturally found in your body to regenerate collagen, elastin, and other key proteins by activating skin’s natural pathway for self-renewal.

Explore how RADIESSE renews skin quality and restores natural contour in the areas where you may notice signs of aging—the lower face, hands, and jawline.

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    Actual patient. Individual results may vary.
    Actual patient. Individual results may vary.

    Treatment Plan

    Debra, age 62, after being injected with 2.9 cc of RADIESSE (+) in the midface to treat the lower face and 2.8 cc of RADIESSE in different wrinkles in the lower face.

    Marionette Lines

    These lines run downward from the corners of the mouth to the chin. RADIESSE can provide structural support to lift the corners and correct the downturned appearance.

    Smile Lines

    These are the creases (nasolabial folds) that run from the nose to the corners of the mouth. RADIESSE can restore volume and correct the deepening of these folds that occurs with aging.

    Pre-Jowl Folds

    These are the subtle hollows that appear on either side of the chin; RADIESSE restores volume to create a smoother, more defined jawline contour.

    Corners of the Mouth

    Volume loss here can cause the mouth to look downturned. RADIESSE supports the oral commissures for a more lifted expression.

    Chin Wrinkles

    These are the horizontal lines that crease the chin. RADIESSE adds foundational support to smooth creases and restore a refined contour to the lower face.

    Actual patient. Individual results may vary.
    Actual patient. Individual results may vary.

    Treatment Plan

    Andrea, age 42, 2 weeks after being injected with 3 mL of RADIESSE to treat the hands.

    RADIESSE Can Enhance the Appearance of Hands by:

    • Restoring volume loss, which contributes to the signs of aging
    • Minimizing the visibility of veins and tendons
    Actual patient. Individual results may vary.
    Actual patient. Individual results may vary.

    Treatment Plan

    Jean, age 57, 4 weeks after being injected with 3.5 cc of RADIESSE (+) in the lower face to treat the jawline.

    RADIESSE (+) Can Improve Jawline Contour:

    • For adults over the age of 21
    • Effective improvement in moderate to severe loss of jawline contour

    Proven results across 3 key benefits

    RADIESSE is a proven regenerative biostimulator that firms and tightens skin, reversing visible signs of aging from within. Learn more about how RADIESSE delivers these skin benefits along with measurable results from clinical trials that demonstrate its effectiveness.

    Firms

    RADIESSE improves skin firmness, elasticity, and hydration

    RADIESSE utilizes an ingredient that is also naturally found in your body to activate your skin’s regenerative power—boosting collagen, elastin, and other key proteins.

    Need firm numbers? The results are in.

    23x

    More collagen versus placebo*

    96%

    More elastin than baseline*

    48%

    Improved skin thickness versus baseline†

    *Based on 6-month human tissue study versus placebo.
    †Compared to baseline in an 18-month study of 100 patients with human immunodeficiency virus (HIV) facial lipoatrophy.

    Woman pinching her skin showing firm skin
    Not an actual patient.
    Woman touching her skin showing tight skin
    Not an actual patient.

    Tightens

    RADIESSE regenerates key proteins to deliver smoother, tighter skin

    RADIESSE enhances skin vitality by working with your body to strengthen skin structure and improve skin health.

    The proof is in the profile.

    94%

    of patients showed improved smile lines from baseline‡

    78%

    of patients showed tighter skin§

    ‡Study design: In a randomized, split-face study (n=117), 94% of calcium hydroxylapatite–treated folds were rated as improved at 6 months (Global Aesthetic Improvement Scale).
    §Compared to baseline in 20 female subjects with self-evaluated flaccidity scores ≥3 on a 6-point scale (0, no flaccidity; 5, very severe flaccidity) in zones of interest.

    Have questions about how to get results like these? Find answers to this and more.

    Frequently Asked Questions

    Reverses

    RADIESSE reverses visible signs of aging

    RADIESSE is the #1 researched biostimulator in Regenerative Aesthetics publications and is proven to reverse the visible signs of aging.

    For younger, healthier-looking skin, so that you can look your best at any age.II

    Results that go the extra mile

    98%

    patient satisfaction

    2 yrs

    improvements can last up to 2 years#

    See the results that RADIESSE patients found so satisfying.

    Before & After Results

    ‖RADIESSE is not indicated for individuals under the age of 18. Consult your physician to find out if RADIESSE is right for you. Please check your local regulatory approval.
    Study design: In a multicenter, randomized study (n=120), 98% of calcium hydroxylapatite–treated patients self-reported overall satisfaction at 4 months after the second injection.
    #Study design: Based on study that followed 102 patients for over 3 years to test the long-term effects of RADIESSE on smile lines.

    Woman looking forward touching her face with healthy-looking skin
    Not an actual patient.

    Why choose RADIESSE for your skin during your GLP-1 journey?

    RADIESSE can help address facial volume loss associated with rapid weight loss.

    Lose Weight, Not Volume

    GLP-1=glucagon-like peptide-1.

    THE SCIENCE OF Healthier-Looking Skin

    Ready to discover the science behind RADIESSE?

    Take the next step and dive deeper into the science—simplified.

    Regenerate With RADIESSE
    Diverse group of people with healthy-looking skin.

    Actual patients. Individual results may vary.

    What are RADIESSE® and RADIESSE® (+)?

    RADIESSE® and RADIESSE® (+) are dermal fillers that are used for smoothing moderate to severe facial wrinkles and folds, such as nasolabial folds (the creases that extend from the corner of your nose to the corner of your mouth). RADIESSE® is also used for correcting volume loss in the back of the hands. RADIESSE® (+) is also used for improving moderate to severe loss of jawline contour in adults over 21 years old.

    RADIESSE® and RADIESSE® (+) IMPORTANT CONSUMER SAFETY INFORMATION

    Who should not use RADIESSE® or RADIESSE® (+)?

    You should not use RADIESSE® or RADIESSE® (+) if you have an allergy to any component of the product, if you have a history of severe allergies, if you have a bleeding disorder, or if you are pregnant or breastfeeding. You should not use RADIESSE® (+) if you have an allergy to lidocaine or medicines like it.

    What is the most important information I should know about RADIESSE® and RADIESSE® (+)?

    One of the risks with using these products is unintentional injection into a blood vessel. The chances of this happening are very small, but if it does happen, the complications can be serious, and may be permanent. These complications, which have been reported for facial injections, can include vision abnormalities, blindness, stroke, temporary scabs, or permanent scarring of the skin. If you have changes in your vision, signs of a stroke (including sudden difficulty speaking, numbness or weakness in your face, arms, or legs, difficulty walking, face drooping, severe headache, dizziness, or confusion), white appearance of the skin, or unusual pain during or shortly after treatment, you should notify your health care practitioner immediately.

    As with all procedures that involve an injection through the skin, there is a risk of infection.

    Do not use RADIESSE® or RADIESSE® (+) if you have a skin infection until it has healed.

    It is not known if RADIESSE® or RADIESSE® (+) is safe or effective in the lips, or in the area around the eyes.

    It is not known if RADIESSE® or RADIESSE® (+) is safe or effective beyond 3 years in the face and 1 year in the hand.

    Injection of RADIESSE® (+) into the jawline may temporarily alter jaw function.

    The microspheres in RADIESSE® and RADIESSE® (+) can be seen in X-rays and CT Scans. It is very important that you tell your health care provider that you have had RADIESSE® or RADIESSE® (+) dermal filler.

    If you have a history of herpes, you may experience a herpes breakout after receiving RADIESSE® or RADIESSE® (+).

    Injection in the back of the hand may result in temporary difficulty performing activities. RADIESSE® may cause nodules, bumps or lumps in the back of the hand and can last up to 1 year.

    You should minimize strenuous activity and avoid extensive sun or heat exposure for about 24 hours after treatment and until any swelling or redness has resolved.

    What should I tell my doctor before using RADIESSE® or RADIESSE® (+)?

    Tell your health care provider if you are taking blood thinners or medicines that can interfere with the clotting of blood, such as aspirin or warfarin. These medicines might make it more likely that you will experience bruising or bleeding at the injection site. Tell your health care provider if you have any diseases, injuries or disabilities of the hand, if you have a history forming large, raised scars or if you have had any other skin treatments such as skin peels.

    What are the most common adverse events with RADIESSE® or RADIESSE® (+)?

    The most common adverse events seen in clinical studies of RADIESSE® used in the hands include bruising, redness, swelling, pain, itching, nodules or bumps/lumps, difficulty performing activities, loss of sensation and other local side effects. The most common adverse events seen in clinical studies of RADIESSE® or RADIESSE® (+) used in the face include bruising, redness, swelling, pain, itching, difficulty chewing, and other local side effects.

    Delayed-onset inflammation near the site of injection is one of the known adverse events associated with dermal fillers. Cases of delayed-onset inflammation have been reported to occur at the treatment site following viral or bacterial illnesses or infections, vaccinations, or dental procedures. Typically, the reported inflammation was responsive to treatment or resolved on its own.

    These are not all of the possible side effects with RADIESSE® or RADIESSE® (+). Merz collects information about adverse events seen with RADIESSE® and RADIESSE® (+) outside of clinical studies. These events are included in the RADIESSE® and RADIESSE® (+) Patient Information Guide based on an assessment of seriousness and potential causal relationship to RADIESSE® or RADIESSE® (+). Please see the Patient Information Guide available at www.radiesse.com for list of these events. Tell your health care provider about any side effects that bother you or do not go away.

    Important: For full safety information, please visit www.Radiesse.com or call MyMerz Solutions at 1-844-469-6379

    RADIESSE® and RADIESSE® (+) are available by prescription only.