For Healthcare Providers

Re-Awaken Skin From Within

REGENERATE WITH RADIESSE

The Science of Healthier-Looking Skin

Discover how RADIESSE uses an ingredient that is also naturally found in your body to activate your skin’s regenerative power—boosting collagen, elastin, and other key proteins.

Science You Can Feel

The regenerative science of RADIESSE–explained simply

RADIESSE is a regenerative biostimulator that boosts collagen, elastin, and key proteins in your skin. Our high-quality microspheres deliver firmer, tighter skin, proven to reverse visible signs of aging.

RADIESSE has been shown to boost collagen production up to 23x and increase elastin by 96%.1*

For a future that is smoother and more radiant, RADIESSE. Re-Awaken skin from within.

Talk to your healthcare professional to see if RADIESSE is right for you.

*Based on 6-month human tissue study versus placebo.

Reference: 1. Data on file. Merz North America, Inc. 2025.

Understanding skin aging

As early as age 25, collagen production declines by approximately 1.0% to 1.5% every year.1 Furthermore, elastin fibers become increasingly fragmented after age 40.2 The loss of key structural proteins like collagen and elastin can lead to thinner, more fragile skin.2

Beyond changes to skin’s quality, the entire facial structure changes as well. Beginning in your late 30s and 40s, facial fat shifts and shrinks, and even the underlying bone density decreases, leading to sinking, sagging, and deeper wrinkles.3

References:
1. Reilly DM, et al. Plast Aesthet Res. 2021;8:2.
2. Jiang F, et al. Sci Rep. 2025;15:28598.
3. Swift A, et al. Aesthet Surg J. 2021;41(10):1107-1119.

Comparison pictures showing the differences between 25 years and 65 years.
Not an actual patient.
Man with salt and pepper hair and beard.
Actual patient. Individual results may vary.

RADIESSE is key

RADIESSE’s regenerative power lies in its ability to activate skin’s natural pathway to self-renewal. When RADIESSE is injected, it provides a “scaffold” that helps enable collagen and elastin to regenerate.

Skin renewal across 5 distinct measures of skin health

RADIESSE doesn’t just treat one issue—it makes skin healthier by targeting several important building blocks of skin health that gradually take effect and reinforce each other over time.

SUPPORT

Collagen Type I

Replenishing this type of collagen provides the skin with strength and
resilience.1-5

STRUCTURE

Collagen Type III

This type of collagen creates an organized structure within your skin. This organized scaffolding is what differentiates the regenerative process of RADIESSE from undifferentiated collagen stimulation, such as scar tissue formation.1-5

ELASTICITY

Elastin

Regenerating this component inside the skin restores youthful “bounce” and recoil to combat age-related sagging.2-6

GLOW

Proteoglycans

These proteins help skin hold onto moisture, supporting a plump, hydrated glow.3,6

NOURISH

Angiogenesis

This is the process through which RADIESSE generates new blood flow to nourish skin tissue, supporting a pathway for oxygen and nutrients to maintain skin health.1,4,5

References:
1. Yutskovskaya YA, et al. J Drugs Dermatol. 2017;16(1):68-74.
2. Yutskovskaya Y, et al. J Drugs Dermatol. 2014;13(9):1047-1052.
3. Nowag B, et al. CaHA microspheres: contact with fibroblasts and amount of spheres are key factors for collagen stimulation. Presented at: AMWC 2020; Monte Carlo, Monaco; April 2-4, 2020.
4. Yutskovskaya YA, et al. J Drugs Dermatol. 2020;19(4):405-411.
5. Aguilera SB, et al. Aesthet Surg J. 2023;43(10):1063-1090.
6. González N, et al. Dermatol Surg. 2019;45(4):547-551.

Biostimulation replenishes the skin

Actual patient. Individual results may vary.
Actual patient. Individual results may vary.

It’s easy to think all injectable treatments are the same, but RADIESSE is what’s known as a biostimulator because it stimulates the skin’s regeneration process. Biostimulators target the body’s natural support structure to replenish its important building blocks.

Unlike some biostimulators that rely on the body’s immune system to work, RADIESSE works via a non-inflammatory pathway using an ingredient that also naturally occurs in your body.

This allows RADIESSE to produce results that continue to gradually develop over time, providing results that can last up to 2 years.

But this isn’t just theoretical—see how the science translates to real patient results in the Before & Afters gallery.

See Before & Afters

For RApID Weight-Loss Patients 

On your rapid weight loss journey?

Rapid weight loss can affect more than just the body. Learn more about using RADIESSE to help address facial volume loss associated with rapid weight loss.

For Rapid Weight Loss
Diverse group of people smiling.

Actual patients. Individual results may vary.

What are RADIESSE® and RADIESSE® (+)?

RADIESSE® and RADIESSE® (+) are dermal fillers that are used for smoothing moderate to severe facial wrinkles and folds, such as nasolabial folds (the creases that extend from the corner of your nose to the corner of your mouth). RADIESSE® is also used for correcting volume loss in the back of the hands. RADIESSE® (+) is also used for improving moderate to severe loss of jawline contour in adults over 21 years old.

RADIESSE® and RADIESSE® (+) IMPORTANT CONSUMER SAFETY INFORMATION

Who should not use RADIESSE® or RADIESSE® (+)?

You should not use RADIESSE® or RADIESSE® (+) if you have an allergy to any component of the product, if you have a history of severe allergies, if you have a bleeding disorder, or if you are pregnant or breastfeeding. You should not use RADIESSE® (+) if you have an allergy to lidocaine or medicines like it.

What is the most important information I should know about RADIESSE® and RADIESSE® (+)?

One of the risks with using these products is unintentional injection into a blood vessel. The chances of this happening are very small, but if it does happen, the complications can be serious, and may be permanent. These complications, which have been reported for facial injections, can include vision abnormalities, blindness, stroke, temporary scabs, or permanent scarring of the skin. If you have changes in your vision, signs of a stroke (including sudden difficulty speaking, numbness or weakness in your face, arms, or legs, difficulty walking, face drooping, severe headache, dizziness, or confusion), white appearance of the skin, or unusual pain during or shortly after treatment, you should notify your health care practitioner immediately.

As with all procedures that involve an injection through the skin, there is a risk of infection.

Do not use RADIESSE® or RADIESSE® (+) if you have a skin infection until it has healed.

It is not known if RADIESSE® or RADIESSE® (+) is safe or effective in the lips, or in the area around the eyes.

It is not known if RADIESSE® or RADIESSE® (+) is safe or effective beyond 3 years in the face and 1 year in the hand.

Injection of RADIESSE® (+) into the jawline may temporarily alter jaw function.

The microspheres in RADIESSE® and RADIESSE® (+) can be seen in X-rays and CT Scans. It is very important that you tell your health care provider that you have had RADIESSE® or RADIESSE® (+) dermal filler.

If you have a history of herpes, you may experience a herpes breakout after receiving RADIESSE® or RADIESSE® (+).

Injection in the back of the hand may result in temporary difficulty performing activities. RADIESSE® may cause nodules, bumps or lumps in the back of the hand and can last up to 1 year.

You should minimize strenuous activity and avoid extensive sun or heat exposure for about 24 hours after treatment and until any swelling or redness has resolved.

What should I tell my doctor before using RADIESSE® or RADIESSE® (+)?

Tell your health care provider if you are taking blood thinners or medicines that can interfere with the clotting of blood, such as aspirin or warfarin. These medicines might make it more likely that you will experience bruising or bleeding at the injection site. Tell your health care provider if you have any diseases, injuries or disabilities of the hand, if you have a history forming large, raised scars or if you have had any other skin treatments such as skin peels.

What are the most common adverse events with RADIESSE® or RADIESSE® (+)?

The most common adverse events seen in clinical studies of RADIESSE® used in the hands include bruising, redness, swelling, pain, itching, nodules or bumps/lumps, difficulty performing activities, loss of sensation and other local side effects. The most common adverse events seen in clinical studies of RADIESSE® or RADIESSE® (+) used in the face include bruising, redness, swelling, pain, itching, difficulty chewing, and other local side effects.

Delayed-onset inflammation near the site of injection is one of the known adverse events associated with dermal fillers. Cases of delayed-onset inflammation have been reported to occur at the treatment site following viral or bacterial illnesses or infections, vaccinations, or dental procedures. Typically, the reported inflammation was responsive to treatment or resolved on its own.

These are not all of the possible side effects with RADIESSE® or RADIESSE® (+). Merz collects information about adverse events seen with RADIESSE® and RADIESSE® (+) outside of clinical studies. These events are included in the RADIESSE® and RADIESSE® (+) Patient Information Guide based on an assessment of seriousness and potential causal relationship to RADIESSE® or RADIESSE® (+). Please see the Patient Information Guide available at www.radiesse.com for list of these events. Tell your health care provider about any side effects that bother you or do not go away.

Important: For full safety information, please visit www.Radiesse.com or call MyMerz Solutions at 1-844-469-6379

RADIESSE® and RADIESSE® (+) are available by prescription only.